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Index > Protein center > IGFBP3(Gene name) > Human
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  • IGFBP3 (Gene name),
  • Insulin-like growth factor-binding protein 3 (Protein name ),  IBP3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    IGFBP3(IBP3);
    Protein name:
    Insulin-like growth factor-binding protein 3(IBP-3;IGF-binding protein 3;IGFBP-3);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN.
    Function:
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    291
    Sequence:
    50:
    MQRARPTLWA | AALTLLVLLR | GPPVARAGAS | SAGLGPVVRC | EPCDARALAQ | 
    100:
    CAPPPAVCAE | LVREPGCGCC | LTCALSEGQP | CGIYTERCGS | GLRCQPSPDE | 
    150:
    ARPLQALLDG | RGLCVNASAV | SRLRAYLLPA | PPAPGNASES | EEDRSAGSVE | 
    200:
    SPSVSSTHRV | SDPKFHPLHS | KIIIIKKGHA | KDSQRYKVDY | ESQSTDTQNF | 
    250:
    SSESKRETEY | GPCRREMEDT | LNHLKFLNVL | SPRGVHIPNC | DKKGFYKKKQ | 
    291:
    CRPSKGRKRG | FCWCVDKYGQ | PLPGYTTKGK | EDVHCYSMQS | K
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    MIM:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human IBP-3
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    E0054r
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    ELISA Kit for Human IBP-3
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    E0054b
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    ELISA Kit for Human IBP-3
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    ELISA Kit for Human IBP-3
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    E0054m
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    ELISA Kit for Human IBP-3
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    E0054p
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    CLIA Kit for Human IBP-3
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    U0054p
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    96T
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    CLIA Kit for Human IBP-3
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    U0054m
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    96T
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    CLIA Kit for Human IBP-3
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    U0054h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human IBP-3
    Cat.:
    U0054b
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    96T
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    CLIA Kit for Human IBP-3
    MSDS:
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    Polyclonal Antibody for Human IBP-3
    Cat.:
    P0054Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IBP-3
    Polyclonal Antibody for Human IBP-3
    Cat.:
    P0054Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IBP-3
    Polyclonal Antibody for Human IBP-3
    Cat.:
    P0054Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IBP-3
    Monoclonal Antibody for Human IBP-3
    Monoclonal Antibody for Human IBP-3
    Monoclonal Antibody for Human IBP-3
    Monoclonal Antibody for Human IBP-3
    Protein for Human IBP-3
    Protein for Human IBP-3
    Protein for Human IBP-3
    Protein for Human IBP-3
    Protein for Human IBP-3

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    References
    1. 1.
      "Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein."
      Wood W.I. , Cachianes G. , Henzel W.J. , Winslow G.A. , Spencer S.A. , Hellmiss R. , Martin J.L. , Baxter R.C.
      Mol. Endocrinol.2:1176-1185(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-32
    2. 2.
      "Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity."
      Cubbage M.L. , Suwanichkul A. , Powell D.R.
      J. Biol. Chem.265:12642-12649(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT GLY-32
    3. 3.
      "Analysis of the primary structure of insulin-like growth factor binding protein-3 cDNA from Werner syndrome fibroblasts."
      Thweatt R. , Fleischmann R. , Goldstein S.
      DNA Seq.4:43-46(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-32
      tissue: Skin.
    4. 4.
      NIEHS SNPs program
      Submitted (2005-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2);VARIANTS THR-56 AND SER-234
    5. 5.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
      tissue: Spleen.
    8. 9.
      "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia."
      Zapf J. , Kiefer M. , Merryweather J. , Musiarz F. , Bauer D. , Born W. , Fischer J.A. , Froesch E.R.
      J. Biol. Chem.265:14892-14898(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-65
    9. 10.
      "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species."
      Roghani M. , Segovia B. , Whitechurch O. , Binoux M.
      Growth Regul.1:125-130(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-45;INTERACTION WITH IGF2;VARIANT GLY-32
      tissue: Cerebrospinal fluid.
    10. 11.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-42
    11. 12.
      "Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis."
      Ikonen M. , Liu B. , Hashimoto Y. , Ma L. , Lee K.W. , Niikura T. , Nishimoto I. , Cohen P.
      Proc. Natl. Acad. Sci. U.S.A.100:13042-13047(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HN
    12. 13.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136
      tissue: Plasma.
    13. 14.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136 AND ASN-199
      tissue: Plasma.
    14. 15.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136
      tissue: Liver.
    15. 16.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-116; ASN-136 AND ASN-199
    16. 17.
      "Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer."
      Ingermann A.R. , Yang Y.F. , Han J. , Mikami A. , Garza A.E. , Mohanraj L. , Fan L. , Idowu M. , Ware J.L. , Kim H.S. , Lee D.Y. , Oh Y.
      J. Biol. Chem.285:30233-30246(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TMEM219
    17. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-7 AND CYS-252
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